Karnak can refer to:
- Karnak (TFE) - level in Serious Sam: The First Encounter, Serious Sam: Xbox, Serious Sam HD: The First Encounter, and Serious Sam Classics: Revolution.
- Karnak Demo - demo level in Serious Sam: The First Encounter.
- Karnak (location) - location in Serious Sam: The First Encounter and Serious Sam 3: BFE.
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