The MK IV's grenades significantly bounce more than the grenades fired by the MK III Grenade Launcher, making lobbing grenades around corners much more useful and practical because of the better physics system.
Charged up grenades can be very useful against medium-strength foes because of its power and speed, but the player should remember that, if a grenade misses, there is a chance of the grenade flying back because of how fast it is.
Like the MK III Grenade Launcher, uncharged grenades can be used to take down tightly-packed groups of weak enemies, such as Orc Grunts.
Charged up grenades are not recommended to be used in tight spaces because of the possibility of splash damage and because how fast the grenade is. A fast grenade bounces around longer, making a missed shot very dangerous.