Major Biomechanoid can refer to:
- Major Biomechanoid (SS1) - enemy in Serious Sam 1 and Serious Sam HD.
- Major Biomechanoid (SS3) - enemy in Serious Sam 3: BFE
- Major Biomechanoid (NE) - enemy in Serious Sam: Next Encounter
- Major Biomechanoid (DD) - enemy in Serious Sam: Double D
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