The minigun fires faster than the M1A2 Thompson and generally any other weapon, but its ammunition depletes relatively quickly, though there is a delay before firing as the barrels need to spin up to full speed.
In Serious Sam HD, the minigun fires at a slower rate than previous games, but it deals double damage per shot, which means it spends less ammo than usual.
In Serious Sam 3: BFE, like its many previous incarnations, it still functions as a powerful crowd control weapon, able to cut down waves of enemies like grass.
Tap the trigger to keep the minigun ready to fire, but do not attack unless enemies spawn.
Can be used to kill smaller enemies or wound bigger ones.
It is one of the best anti-Major Bio-mechanoid weapons, since you can destroy their rockets fast and wound them even faster. However, it drains ammo very quickly, and it does take a while to kill them, which may distract you when other enemies are attacking you if you concentrate your fire on the Bio-mechanoid rather than on hordes of enemies.
In Serious Sam HD, it can no longer wound beheaded enemies since it deals double damage, which is instant death to them.
During the level The Dark Bride, if you spot the minigun, do not pick it up and stay behind it. It may be tempting to try out the weapon, but just let the Minigun Turret do the shooting against the enemy until it's over, as picking it up will waste the ammunition of the minigun and you have to take care of the enemy by yourself.
It deals enough damage quickly enough to stun Scrapjacks (to perform a melee grab) on Normal, Hard and Serious difficulty.
The minigun is best used against medium-strength enemies, especially during close combat. As minigun fire is less controllable than the assault rifle, it should not be used against small and medium-sized groups of weak enemies.